蛋白质分选研究进程

蛋白质分选研究进程

摘要： 蛋白质一般在位于细胞质中的核糖体内合成, 但是它们发挥生理功能的地点却分布在细胞的不同区域, 这些区域通常由蛋白质所不能自由透过的脂膜所包裹。因此, 细胞质中新合成的蛋白质必须进行准确的定向运输才能保证各项生命活动的正常运行。研究发现, 一般情况下, 新生蛋白通常在位于其N端的信号肽的指引下到达细胞特定区域, 并由其介导跨膜转运。本文重点介绍信号肽的结构、功能及作用机制等的研究成果。 关键词:蛋白质分选; 信号假说; 信号识别颗粒；信号肽; 核定位信号

Abstract: the protein in the cytoplasm general of the body synthetic DNA, but they play the location of the physiological function but distribution in different areas of the cells, these areas by protein can usually free of fat membrane

through the parcel. Therefore, the new synthesis of protein in the cytoplasm of the directional transportation must be accurate to guarantee the normal operation of the various life activities. Study found that, in general, usually

located in its new protein in N the signal peptide under the guidance of the cells to specific area, and the mediated transport through membrane. This article introduced the signal peptide structure, function and function mechanism research achievements.

Keywords: protein separation; The signal hypothesis; Signal recognition particle; The signal peptide; Approved a signal

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