窒整垦壁垄生塑主兰垒丝圭
一——
tumorinvasion,distantmetastasis
andtumorstaging,butthe
5yearpostoperation
survivalrateofpatientswassignificantlycorrelatedwithdepthofturnerinvasion,
lymph
node
metastasis,distantmetastasis
and
tumor
staging;The
3,5
year
postoperation
survival
rates
ofpatients
withhighly
expression
ofPTENwere
significantly
higherthanthosewithreducedexpressionofPTEN;The3,5yearpostoperationsurvivalratesofpatientswithpositivelyexpressionofVEGFandMMP2
were
significantly
lower
thanthosewithnegatively
expressionofVEGFand
MMP2;Kaplan—Meiersurvival
curves
alsoshowedthatthesurvivaltimeofpatientswith
hi曲ly
expressionofPTENweresignificantlylonger
thanthosewithreducedexpres.sionof
PTEN,Log—ranktest,P<O,05,butthesurvivaltimeofpatientswithpositivelyexpression
ofVEGFand
MMP2weresignificantlyshorterthanthosewimnegativelyexpression
of
VEGFandMMP2,Log—ranktest,P<0.01;Univariate
analysisusing
Coxproportional
hazardsmodelfoundthatprognosisofpatientswithgastriccarcinomawassignificantly
correlatedwithdepth
oftumor
invasion,lymph
node
metastasis,distantmetastasis,
tumorstaging
andexpressionofPTEN,VEGF
and
MMP2;Multivariateanalysisusing
Coxproportionalhazardsmodelfoundthatdepthoftumor
invasion,lymph
node
metastasis,tqlmorstaging
and
expressionofVEGFand
MMP2in
gastriccarcinoma
wereindependentriskfactors,bntexpressionofPTENwasnotindependentriskfactor.
Conclusion(1)Expression
ofPTENingastriccarcinomawassignificantlylower
than
thatinnormalgastrictissues
andreducedexpressionofPTENcouldhelpthediagnosis
ofgastriccarcinomaatearly
stage.佗)Expression
ofPTEN,VEGFandMMP2
significantly
correlatedwithclinicalandbiologicalfactors
andthey
were
important
factors
determining
molecularand
biological
features
of
gastric
carcinoma.
(3)ExpressionofPTENsignificantlycorrelatedwith
thatofVEGF
andMMP2.PTEN
couldsuppresstumorinvasionandmetastasisbymeans
ofregulatingtheexpressionof
VEGF
andMMP2.(4)Reducedexpression
ofPTENandhigblyexpressionofVEGF
andMMP2promotedtumorinvasionandmetastasisingastriccarcinoma.Detecting
S
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