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PTEN、VEGF和MMP2在胃癌组织中的表达及其与胃癌浸润、转移和预后(5)

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童丝垦茎垄兰壁主兰垡鱼查

ExpressionofPTEN,VEGFand

MMP2andTheirCorrelation

withTumorInvasion,MetastasisandPrognosisinHumanGastric

Carcinoma

Abstract

objectiveToinvestigatetheexpressionofPTEN,VEGFandMMP2ingastric

carcinoma,andtoidentifytherelationshipbetweenexpressionofPTEN,VEGFand

MMP2and

theircorrelationwithtumorinvasion,metastasisand

prognosis.Methods

80patientswimgastriccarcinomawhounderwentsurgicalresectionbetween1995.1and1998.6attheFistAffiliatedHospital,Anhui

MedicalUniversitywerefollowed

up,

Expression

of

PTEN,VEGF

andMMP2

was

examined

by

SP—method

immunohistochemistryinall80archivalparaffinernbeddedgastriccarcinomatissuespecimens,and

expression

of

PTEN

was

also

examined

by

SP-method

immunohistochemistryin20normalgastrictissuespecimensinthesametime

as

controlgroups.TherelationshipofPTEN,VEGFandMMP2andtheirrelationshipwith

clinical

and

biologicfactorsandprognosisWas

analyzedbySPSS11.5forWindows

software.Results(1)ExpressionofPTENingastriccarcinoma

35/80(43.8%1

was

significantly

lowerthanthat

innormal

gastric

tissues

19/20(95.0%),

P<0.01;(2)ExpressionofPTEN

was

significantlycorrelatedwithpatients’age,t13amor

differentiation,depthoftumorinvasion,lymphnode

metastasis,distantmetastasis

and

tumorstaging,butwasn’tcorrelatedwithpatients’gendegtumorsizeand

tulTIOr

growth.(3)ExpressionofVEGFandMMP2significantlycorrelatedwith

tumor

size、

ttLrrlor

differentiation,depth

oftumor

invasion,lymphnodemetastasis,distant

metastasisandtumorsta百ng,butwasn’tcorrelatedwithpatients’age,patients’gender

and

tunlor

growth.(4)ExpressionofPTENwasnegativelycorrelatedwiththatofVEGFandMMP2;ExpressionofVEGF

waspositivelycorrelatedwiththat

ofMMP2.(5)The

3yearpostoperationsurvivalrateofpatientsWas

significantlycorrelatedwithdepthof

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