童丝垦茎垄兰壁主兰垡鱼查
ExpressionofPTEN,VEGFand
MMP2andTheirCorrelation
withTumorInvasion,MetastasisandPrognosisinHumanGastric
Carcinoma
一
Abstract
objectiveToinvestigatetheexpressionofPTEN,VEGFandMMP2ingastric
carcinoma,andtoidentifytherelationshipbetweenexpressionofPTEN,VEGFand
MMP2and
theircorrelationwithtumorinvasion,metastasisand
prognosis.Methods
80patientswimgastriccarcinomawhounderwentsurgicalresectionbetween1995.1and1998.6attheFistAffiliatedHospital,Anhui
MedicalUniversitywerefollowed
up,
Expression
of
PTEN,VEGF
andMMP2
was
examined
by
SP—method
immunohistochemistryinall80archivalparaffinernbeddedgastriccarcinomatissuespecimens,and
expression
of
PTEN
was
also
examined
by
SP-method
immunohistochemistryin20normalgastrictissuespecimensinthesametime
as
controlgroups.TherelationshipofPTEN,VEGFandMMP2andtheirrelationshipwith
clinical
and
biologicfactorsandprognosisWas
analyzedbySPSS11.5forWindows
software.Results(1)ExpressionofPTENingastriccarcinoma
35/80(43.8%1
was
significantly
lowerthanthat
innormal
gastric
tissues
19/20(95.0%),
P<0.01;(2)ExpressionofPTEN
was
significantlycorrelatedwithpatients’age,t13amor
differentiation,depthoftumorinvasion,lymphnode
metastasis,distantmetastasis
and
tumorstaging,butwasn’tcorrelatedwithpatients’gendegtumorsizeand
tulTIOr
growth.(3)ExpressionofVEGFandMMP2significantlycorrelatedwith
tumor
size、
ttLrrlor
differentiation,depth
oftumor
invasion,lymphnodemetastasis,distant
metastasisandtumorsta百ng,butwasn’tcorrelatedwithpatients’age,patients’gender
and
tunlor
growth.(4)ExpressionofPTENwasnegativelycorrelatedwiththatofVEGFandMMP2;ExpressionofVEGF
waspositivelycorrelatedwiththat
ofMMP2.(5)The
3yearpostoperationsurvivalrateofpatientsWas
significantlycorrelatedwithdepthof
4
7
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