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脱细胞真皮基质体内转归的研究进展(3)

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    4  问题与展望
    外伤、烧伤和肿瘤术后造成的组织缺损是外科系统常见病症,组织缺损的修复是许多学者致力研究的课题,ADM的出现为组织缺损的修复提供了新的治疗途径。
    ADM遵循组织再生规律的转归是个漫长的过程,受到诸多干扰。体内复杂的微环境中何种因子或因素起主导作用尚不清楚;成纤维细胞是转归的基础性细胞,如何提高维持其作用尚需要解决,如何保证组织再生的彻底性也需要进一步努力。相信随着研究的深入,上述问题会逐渐得以解决。

【参考文献】
  [1] Chaplin JM, Costantino PD, Wolpoe ME. Use of an acellular dermal allograft for dural replacement: an experimental study[J]. Neurosurgery, 1999, 45 (2): 320-327.

[2] Haynes DS, Vos JD, Labadie RF. Acellular allograft dermal matrix for tympanoplasty[J].Curr Opinion Otolaryngol Head Neck Surg, 2005, 13 (5): 283-286.

[3] Gaspar K, Erdei I, Peter Z,et al. Role of acellular dermal matrix allograft in minimal invasive coverage of deep burn wound with bone exposed-case report and histological evaluation[J].Interna Wound J, 2006, 3 (1): 51-58.

[4] Sallum EA, Nogueira-Filho GR, Casati MZ, et al. Coronally positioned flap with or without acellular dermal matrix graft in gingival recessions: a histometric study[J].Am J Dent, 2006, 19 (2): 128-132.

[5] Walter RJ, Matsuda T, Reyse HM, et al.Characterization of acellular dermal matrices (ADMS) prepared by two different methods[J]. Burns,1998, 24(2):104-113.

[6] Cummings LC, Kaldahl WB, Allen EP. Histological evaluation of autogenous connective tissue and acellular dermal matrix grafts in humans[J]. J Periodontol, 2005, 76 (2): 178-186.

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[8] Thakker MM, Fay AM, Pieroth L,et al. Fibrovascular ingrowth into hydroxyapatite and porous polyethylene orbital implants wrapped with acellular dermis[J]. Ophthal Plast Reconstr Surg, 2004,20(5):368-373.

[9] Tark KC, Chung S, Shin KS,et al. Skin flap prefabrication using acellular dermal matrix and cultured keratinocytes in a porcine model[J]. Ann Plast Surg,2000, 44(4):392-397.

[10]  Wei PC, Laurell L, Lingen MW,et al. Acellular dermal matrix allografts to achieve increased attached gingiva. Part 2.A histological comparative study[J]. Periodontology,2002,73 (3):257-265.

[11] 谢卫国,谭红.真皮替代物移植后的血管化过程及组织学变化的实验研究[J].中华烧伤杂志,2005, 21 (1): 37-39.

[12] Pahari MP, Raman A, Bloomenthal A,et al. A novel approach for intestinal elongation using acellular dermal matrix: an experimental study in rats[J]. Transplant Proc,2006, 38(6):1849-1850.

[13] Buinewicz B, Colony LH, Smith RJ. The use of human acellular tissue matrix in abdominal wall reconstruction-A clinical perspective[J]. Life Cell Clinic Momogr Series, 2003.

[14] Witt PD, Cheng CJ, Mallory SB. Surgical treatment of pseudosyndactyly of the hand in epidermolysis bullosa: histological analysis of an acellular allograft dermal matrix[J].Ann Plast Surg, 1999, 43 (4): 379-385.

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