DBPT-drinking freely-high dose
1.5g·kg·d
-1-1
11
5.8±0.3 4.2±0.2 3.6±1.2 4.9±0.4 4.6±0.3
表3 不同给药方式对KKAy小鼠饮水量的影响（x?s，ml）
Tab. 3 The effects of different administration methods on the water-intake of KKAy mice（x?s，ml）
Group
Control KKAy Model
Positive drug group DBPT-ig-low dose DBPT-ig-middle dose DBPT-ig-high dose
n Week 0
10 5.7±0.8 11 15.7±3.3
11 -1-1
1.33mg·kg·d 14.9±2.6 0.375g·kg-1·d-1 0.75g·kg-1·d-1 1.5g·kg-1·d-1
11 11 11
12.1±3.2 16.8±6.8 13.7±1.8
Dose
Week 1
5.2±1.0 16.8±4.8 12.0±3.4 12.3±3.4 14.6±5.9 14.9±1.9 5.3±1.3 4.5±1.8 5.0±2.4
Week 2 4.8±0.8 20.4±2.8 12.6±3.2 12.1±3.2 16.8±6.8 9.64±1.4 8.36±1.8 6.2±1.7 7.3±1.3
Week 3 4.9±1.0 18.5±3.7 8.1±3.5 13.2±3.9 14.8±5.6 6.6±2.9 7.0±3.0 7.6±2.9 7.5±1.7
Week 4 4.5±1.8 17.6±4.6 7.7±3.3 12.1±3.4 13.2±2.9 8.8±2.4 7.2±3.3 7.9±2.9 7.3±3.1
DBPT-drinking freely-low 11
16.1±2.2 0.375g·kg-1·d-1
dose
DBPT-drinking 11 -1-1
0.75g·kg·d 16.5±1.8
freely-middle dose
DBPT-drinking freely-high 11
15.0±2.4 1.5g·kg-1·d-1
dose
11
表4 不同给药方式对KKAy小鼠的空腹血糖影响（mmol/L）
Tab. 4 The effects of different administration methods for FBG in KKAy mice（mmol/L） Group
Control KKAy Model
Positive drug group
1.33mg·kg-1·d
-1
Dose
n Week 0 10 7.6±0.7 11
19.6±4.3 11
19.6±4.3 11
19.5±4.2 11 11 11
19.5±4.8 11 11
19.6±5.0 19.4±4.2 19.4±4.5 19.4±4.6
Week 1 8.1±0.6 26.0±3.8△△△
＊＊
Week 2 7.3±1.0 27.0±2.8△△△ Week 3 7.8±0.6 28.9±2.9△△△ Week 4 7.7±0.6 28.51±3.4△△△
-1
18.9±4.3＊＊19.0±4.0＊＊18.0±4.5＊＊
20.8±3.5 ＊＊＊
20.6±3.4＊＊ 25.8±5.0 21.6±4.5＊
23.2±5.7
29.9±4.6 26.2±5.2
29.9±5.0 26.4±4.8
DBPT-ig-low dose DBPT-ig-middle dose DBPT-ig-high dose DBPT-drinking
freely-low dose DBPT-drinking freely-middle DBPT-drinking freely-high
0.375g·kg·d
-1
0.75g·kg-1·d-1 1.5g·kg·d 0.375g·kg-1·d
-1
-1
-1
18.6±4.5＊＊19.2±4.6＊＊21.2±4.9＊＊21.4±3.7＊＊＊＊＊＊ 21.8±3.5＊＊19.1±3.2＊＊19.3±4.4＊＊22.0±4.4＊＊＊＊＊＊ 15.9±5.3＊＊14.8±3.9＊＊20.3±5.0＊＊18.9±4.2＊＊＊＊＊＊
＊＊＊＊＊＊＊＊
15.5±2.615.1±4.618.5±5.417.0±3.0＊＊＊＊
-1
-1
0.75g·kg·d 1.5g·kg-1·d-1
Note: compared with the model group, ＊p＜0.05, ＊＊p＜0.01, ＊＊＊p＜0.001；compared with the Control group△△△p＜0.001
12
表5 不同给药方式对KKAy小鼠不同时间点血糖及葡萄糖耐量的影响（mmol/L）
Tab. 5 The Statistics of DBPT for BG of different times and glucose tolerance in KKAy mice with different administration
methods（mmol/L）
Blood sugar (mmol/L) AUC(mmol/L·h-1
Group
) 0h 0.5h 1h 2h
Control 7.69±0.62 10.63±1.36 9.14±1.33 8.15±0.91 18.17±1.82 KKAy Model 27.24±5.64 37.93±4.96 36.14±5.41 33.09±3.01 69.42±9.03
18.04±4.57＊28.38±5.09＊26.40±5.13＊＊＊
Positive drug group 33.46±6.90 ＊55.73±9.89 ＊＊＊＊
＊
31.89±4.26
DBPT-ig-low dose 28.82±5.14 ＊35.25±10.47 32.24±3.40 65.71±10.07
＊
21.42±3.76＊＊
DBPT-ig-middle dose 34.53±3.51 32.63±2.87 29.66±3.86 61.92±6.08 ＊
19.24±4.79＊
DBPT-ig-high dose 33.74±3.66＊ 32.36±4.26 29.98±3.47＊ 60.94±4.45＊＊ ＊
＊＊＊
DBPT-drinking freely-low 17.05±4.4930.41±3.3029.98±3.89＊＊＊
29.20±3.64 56.55±6.30 ＊＊＊＊＊
dose DBPT-drinking freely-middle 18.95±4.29＊31.60±4.92＊
32.18±3.82 31.71±3.92 60.53±7.20＊ ＊＊＊
dose
＊＊＊
DBPT-drinking freely-high 17.04±3.0629.62±4.3729.31±4.39
30.15±2.72＊ 56.13±7.42＊＊＊ ＊＊＊＊＊
dose
Note: compared with the model group,＊p＜0.05，＊＊p＜0.01，＊＊＊p＜0.001；
13
80706050403020100rugLl AUC(mmol/L·h-1)图1 普洱茶珍不同给药方式葡萄糖耐量的血糖曲线下面积（AUC）统计
Fig1 The Statistics of Deepure Bio-Puer Tea for AUC in KKAy mice with different administration methods
14
ig-HBPT-drinDk-BPLT-drinDk-BPMT-drink-HDyntroKAig-BPT-Coig- dsitiveDBPT-PoDDBPT-KM14121086420y ModPoelsitive drugDBPT-ig-LDBPT-ig-MDBPT-igD-HBPT-drinDk-BPLT-drink-DBPMT-drink-HInsulin Resistance Index
15
Co
图2 普洱茶珍不同给药方式胰岛素抵抗指数影响的统计
Fig 2 The Statistics of Deepure Bio-Puer Tea for Fasting Insulin in KKAy mice with different administration methods
KKAntrol
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