赵子春，等. 中空多孔金属假体复合诱导因子对骨髓间充质干细胞生长及成骨分化的影响
www.CRTER.org
的研究[39-40]
。实验经过不同时间点的诱导培养之后，发
现中空多孔假体支架复合成骨诱导因子后，其表面细胞呈现梭形生长，出现了明显钙化结节形成，体外实验证实了该中空多孔假体支架复合诱导材料有利于骨髓间充质干细胞的生长，通过中空多孔的间隙注入生长因子，填充了植入宿主骨的潜在间隙，给骨修复生长提供了充足的空间，另外增加成骨生长因素加快了成骨的形成。综上，在前人研究的基础上，将骨组织工程方法与多孔中空金属假体的理念相结合，为更加牢固的生物固定型人工关节和金属骨置入研究提供了更加丰富的实验依据。
感谢：感谢青海大学医学院神经分子实验室老师们提供的技术支持。
作者贡献：赵子春行实验设计，实验实施为李凌伟，实验评估为曹志强，资料收集为李春亮和齐圆圆，赵子春成文，李钊伟审校。
利益冲突：所有作者共同认可文章无相关利益冲突。 伦理问题：实验方案经青海大学大学动物实验伦理委员会批准，批准号为5692541。
文章查重：文章出版前已经过CNKI反剽窃文献检测系统进行3次查重。
文章外审：文章经国内小同行外审专家审核，符合本刊发稿宗旨。
作者声明：文章第一作者对研究和撰写的论文中出现的不端行为承担责任。论文中涉及的原始图片、数据(包括计算机数据库)记录及样本已按照有关规定保存、分享和销毁，可接受核查。
文章版权：文章出版前杂志已与全体作者授权人签署了版权相关协议。
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P.O. Box 10002, Shenyang 110180 www.CRTER.org
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