5th Asia Pacific ISSX Meeting 2014

5th Asia Pacific ISSX Meeting 2014 May 9-12, 2014 Binhai One Hot Spring Resort, Tianjin China Hosted by: International Society for Study of Xenobiotics (ISSX) Organized by: Chinese Society for Study of Xenobiotics (CSSX) Co-Organized by: Tianjin Institute of Pharmaceutical Research (TIPR) Committee of Pharmaceutical Engineering of Chinese Pharmaceutical Association (CPECPA) Meeting Management: Shanghai MICE Partners Consulting Co., Ltd (SMPC) Meeting Organizing Committee Changxiao Liu, Meeting Co-Chair, Tianjin Institute of Pharmaceutical Research, China Zhuohan Hu, Meeting Co-Chair, Research Institute for Liver Disease, Shanghai, China John Miners, Meeting Co-Chair, Flinders University School of Medicine, Australia Philip Board, Australian National University, Canberra, Australia Min Huang, Sun Yat-sen University, Guangzhou, China Jae-Gook Shin, Inje University, Busan, Republic of Korea Duanyun Si, Tianjin Institute of Pharmaceutical Sciences, Tianjin, China Bill Smith, Pfizer Inc., San Diego, California, USA Jasminder Sahi, GlaxoSmithKline R&D, China Ikumi Tamai, Kanazawa University, Kanazawa, Japan Wichittra Tassaneeyakul, Khon Kaen University, Khon Kaen, Thailand Zhenqing Zhang, Chinese Academy of Military Medical Sciences Dafang Zhong, Shanghai Institute of Materia Medica, Shanghai, China Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA The scientific program, which will run over three days, will comprise two keynote lectures, two award lectures, three workshops, and twelve symposia along with poster sessions. Save the dates and make plans to join us in Tianjin, China! For meeting registration, sponsor and exhibition inquiry, please contact Frank Fung at info@mice-partners.com or visit http://www.cssx.org.cn/2014/APISSX_2014.asp?ID=41 5th Asia Pacific ISSX Meeting Scientific Program

Scientific Program

Day One: Friday, May 9, 2014

17:30-18:00 | Opening and Welcome Remarks

Location: Meeting Centre Lobby, Binhai One Hot Spring Resort, Tianjin China 18:00-18:30 | Sponsored Scientific Lecture Location: Chinese Restaurant Ballroom

Contributions to therapeutic innovation in China by Chinese Academy of Medical Sciences – from PK to PD Dr. Yan Li

18:30-21:00 | Welcome Reception

Location: Chinese Restaurant Ballroom Day Two: Saturday, May 10, 2014 07:00-8:30 | Registration

Location: Meeting Centre Lobby 8:30-9:00 | Opening Remarks Location: Binhai Hall

9:00-10:00 | K1. Keynote Lecture 1: Personalized Medication in China: Current Status and Trends Location: Binhai Hall

Co-chairs: Zhuohan Hu, Research Institute for Liver Diseases, Shanghai, China; Changxiao Liu, Tianjin Institute of Pharmaceutical Research, Tianjin, China

Speaker: Professor Honghao Zhou, Institute of Clinical Pharmacology, Central South China University, Changsha,

China 10:00-10:30 | Refreshment and Posters Review Location: Meeting Centre Foyer

10:30-12:00 | Workshop 1: The Functional Characterization of Transporters Location: Multimedia Room

Co-chairs: Ikumi Tamai, Kanazawa University, Kanazawa, Japan; Kexin Liu, Dalian Medical University, Dalian, China

10:30-11:00 | S1. Species Differences in Drug Transporters Implications in Safety & Efficacy Jasminder Sahi, GlaxoSmithKline R&D, China

11:00-11:30 | S2. Evaluation of Drug Effect on Transporters Regulating Serum Urate Ikumi Tamai, Kanazawa University, Kanazawa, Japan

11:30-12:00 | S3. Drug Transporter Based Pharmacodynamic Screening of Chinese Herbal Medicine Xiulin Yi, Tianjin Institute of Pharmaceutical Sciences

10:30-12:00 | Symposium 1: Genetic Regulation of Drug Metabolising Enzymes Concurrent with Workshop 1 Location: Binhai Hall

Co-chairs: Peter Mackenzie, Flinders University, Bedford Park, Australia; Zhonghui Yuan, Institute of Veterinary Pharmaceuticals, Wuhan, China

10:30-11:00 | S4. PXR: Endo/xeno Dual Sensor that Integrates SGK2 Signaling for Glucogenesis

Masa Negishi, NIH/NIEHS, Research Triangle Park, North Carolina, USA

11:00-11:30 | S5. Regulation of UDP-glucuronosyltransferases in Breast and Prostate Cells: Implications for Cancer

Peter Mackenzie, Flinders University, Bedford Park, Australia

11:30-12:00 | S6. PCB Regulation of Hepatic Nuclear Receptors: Implications for Hepatic Steatosis Russ Prough, University of Louisville School of Medicine, Louisville, Kentucky, USA

12:00-13:00 | Industry Sponsored Symposia

Location: Binhai Hall- Shimadzu & Multimedia Room-Waters 13:00-14:00 | Posters and Exhibitions Location: Meeting Centre Foyer

14:00-15:30 | Symposium 2: Metabolism and Safety of Herbal Medicines and Natural Products – Preclinical/Clinical and Toxicological Significance Location: Binhai Hall

Co-chairs: Changxiao Liu, Tianjin Institute of Pharmaceutical Research, Tianjin, China; Ge Lin, The Chinese University of Hong Kong, Hong Kong, China

14:00-14:30 | S7. Transporters in Drug Safety of Herbal Medicines

Xiaodong Liu, Chinese Pharmaceutical University, Nanjing, China

14:30-15:00 | S8. Translational Science of Herb-drug Interactions: Preclinical to Clinical Soo-Jin Park, Daegu Haany University, Gyeongsan, Korea

15:00-15:30 | S9. Translational Science of Safety of Herbal Medicines and Natural Products: Development of the Mechanism-based Biomonitoring Marker for Clinical Diagnosis Ge Lin, The Chinese University of Hong Kong, Hong Kong, China

14:00-15:30 | Symposium 3: Drug-Drug Interactionss – Mechanisms and Prediction Location: Multimedia Room

Co-chairs: Jianshi Lou, Tianjin Medical University, Tianjin, China; Ling Yang, Dalian Institute of Chemical Physics, CAS, Dalian, China

14:00-14:30 | S10. Application of Physiologically-based Pharmacokinetic Modeling and Simulation in

Prediction of Human PK and Drug-drug Interactions, an Industrial Experience Chuang Lu, Millennium Pharmaceuticals, Takeda Co, Cambridge, Massachusetts, USA

14:30-15:00 | S11. In vitro Prediction of CYP450 Induction: Enzyme/mRNA Induction and Nuclear Receptor Activation

Hongbing Wang, The University of Maryland School of Pharmacy, Baltimore, Maryland, USA

15:00-15:30 | Clinical Drug Interactions through Inhibition of Drug-Metabolizing Enzymes: The Relationship between Substrate, Enzyme and Rate of Reaction Ling Yang, Dalian Institute of Chemical Physics, CAS, Dalian, China

15:30-16:00 | Refreshment and Posters Review Location: Meeting Centre Foyer

16:00-18:00 | Symposium 4: Transporters Location: Multimedia Room

Co-chairs: Jasminder Sahi, GlaxoSmithKline, Shanghai, China; Genfu Chen, Wuxi Apptec, Shanghai, China

16:00-16:30 | S13. OATP Family: Pathophysiological and Pharmacological Roles

Ikumi Tamai, Kanazawa University, Kanazawa, Japan

16:30-17:00 | S14. Leveraging Transporters for the Discovery of CNS drugs Jasminder Sahi, GlaxoSmithKline, Shanghai, China

17:00-17:30 | S15. Human ABC Transporters and Pharmacogenomics Min-Goo Lee, Yonsei University, Seoul, Korea

17:30-18:00 | S16. Amino Acid Transporters in Cancers for Effective and Selective Delivery of Cancer-targeting Agents: Relevance to Cancer Diagnosis and Therapeutics Yoshikatsu Kanai, Osaka University Graduate School of Medicine, Osaka, Japan

16:00-17:30 | Symposium 5: ADME Optimisation in Drug Discovery and Development Location: Binhai Hall

Co-chairs: Bill Smith, Pfizer Inc-La Jolla Labs, San Diego, California, USA; Xiao-dong Liu, China Pharmaceutical University, Nanjing, China

16:00-16:30 | S17. In vitro ADME Approaches in Early Drug Discovery

Yang Sai, Hutchison MediPharma, Shanghai, China

16:30-17:00 | S18. Experiences in the Assessment of DDI Potential during Drug Development: Progress and Challenges

Bill Smith, Pfizer Inc-La Jolla Labs, San Diego, California, USA

17:00-17:30 | S19. ADME Technologies in Drug Discovery and Development Zheming Gu, XenoBiotic Laboratories, Inc., Plainsboro, New Jersey, USA

18:00-20:30 | Banquet

Location: Chinese Restaurant Ballroom Day Three: Sunday, May 11, 2014 08:00-9:00 | Registration

Location: Meeting Centre Lobby

9:00-10:00 | K2. Keynote Lecture 2: Reactive Intermediates versus Covalent Drugs: Similarities and Differences in Chemical Properties and Toxicological Potential Location: Binhai Hall

Co-chairs: John Miners, Flinders University, Bedford Park, Australia; Zhenqing Zhang, Beijing Institute of Pharmacology and Toxicology, Beijing, China Speaker: Tom Baillie, University of Washington, Seattle, Washington, USA 10:00-10:30 | Refreshment and Posters Review Location: Meeting Centre Foyer

10:30-12:00 | Workshop 2: PK-PD Modeling Location: Multimedia Room

Co-chairs: Geoff Tucker, University of Sheffield (Emeritus) and Simcyp Ltd, Sheffield, UK; Xue-hua Jiang, West

China School of Pharmacy, Chengdu, China

10:30-11:00 | S20. Basic Concepts of PK-PD Modelling Jiansong Yang, GlaxoSmithKline, Shanghai, China

11:00-11:30 | S21. PBPK Modelling and its Application in Drug Development Geoff Tucker, University of Sheffield (Emeritus) and Simcyp Ltd, Sheffield, UK 11:30-12:00 | S22. Principles and Practices of POP PK-PD Wei Lu, Beijing University, Beijing, China

10:30-12:00 | Symposium 6: New Approaches for the Study of Drug Disposition Concurrent with Workshop 2 Location: Binhai Hall

Co-chairs: Frank Gonzalez, Laboratory of Metabolism, NCI, NIH, Bethesda, Maryland, USA;

Zack Cheng, AstraZeneca, Shanghai, China

10:30-11:00 | S23. MicroRNAs in Control of Cytochrome P450 Enzyme Mediated Drug Oxidations and Toxicities

Miki Nakajima, Kanazawa University, Kanazawa, Japan

11:00-11:30 | S24. Human Hepatocyte-like Cells and Their Applications Lijian Hui, Shanghai Institute of Biochemistry and Cell Biology, Shanghai, China 11:30-12:00 | S25. Metabolomics in the Study of Drug Metabolism and Toxicity Frank Gonzalez, Laboratory of Metabolism, NCI, NIH, Bethesda, Maryland, USA

12:00-13:00 | Industry Sponsored Symposia

Location: Binhai Hall-Agilent & Multimedia Room-Simulations Plus Inc./Pharmogo 13:00-14:00 | Posters and Exhibitions Location: Meeting Centre Foyer

14:00-15:30 | Poster Oral presentation: 6 speakers Location: Multimedia Room

15:30-16:00 | Refreshment and Posters Review Location: Meeting Centre Foyer

16:00-18:00 | Symposium 7: Herb-Drug Interactions Location: Binhai Hall

Co-chairs: Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China; Xin He, Tianjin University, Tianjin, China

16:00-16:30 | S26. Predicting Herb-drug Interactions via an Integrated in vitro-in silico-in vivo

Approach

Mary Paine, Washington State University, Spokane, Washington, USA

16:30-17:00 | S27. The Genotyping and Phenotyping of Gut Microbiota and its Application for Evaluating Metabolism and Efficacy of Oral Drugs/Herbal Medicines Ru Yan, University of Macau, Macau, China

17:00-17:30 | S28. Potential Herb-drug and Herb-herb Interaction Associated with

Fufang-Danshen-Fang, an Herb Combination for Treatment of Patients with Angina Pectoris Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China

17:30-18:00 | S29. Roles of Efflux Transporters and Metabolizing Enzymes in Herb Induced Hepatotoxicity

Hua Li, Beijing Institute of Pharmacology and Toxicology, Beijing, China

16:00-17:30 | Symposium 8: Advances in Mass Spectrometry–Application to DMPK Science Location: Multimedia Room

Co-chairs: Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA; Duanyan Si, Tianjin Institute of Pharmaceutical Research, Tianjin, China

16:00-16:30 | S30. Unbiased Detection of Totally Unknown Xenobiotics in Complex Biologic Systems

Using High-resolution Mass Spectrometry: Applications in Drug Metabolism and Beyond Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA

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