第1章_药物化学_绪论(13)

先导化合物 Compounds) (Lead Compounds)The lead compound is a prototype compound that has the desired biological or pharmacological activity, but may have many other undesirable characteristics, for example, high toxicity, other biological activities, insolubility, or metabolism problems. The structure of the lead compound is then modified by synthesis to amplify the desired activity and to minimize or eliminate the unwanted properties.

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